Fundació Institut de Bioenginyeria de Catalunya ()

IBEC (www.ibecbarcelona.eu) is a research institute covering most bioengineering fields, from basic research to medical applications, aiming to act as an international reference in this field. IBEC was established in 2005 by the Government of Catalonia, the University of Barcelona (UB) and BarcelonaTech (UPC) and is located at the Barcelona Science Park (PCB). IBEC hosts around 200 researchers and technicians, which are part of its own staff or are associated to the UB and UPC. Within IBEC, the “Nanobioengineering” group (http://www.ibecbarcelona.eu//nanobioengineering) led by Josep Samitier is a multidisciplinary research group focusing its research activities on the development and application of nanotechnology to the development of new biomedical systems and devices, mainly for diagnostic purposes.

Role and Commitment of key persons (including supervisors)

Prof. Josep Samitier (Group Leader) will provide research, training and supervision development of diagnostic biomedical devices and integrated microfluidic devices for organ on chip (20 %). Dr Mª José López (Postdoctoral Researcher): will provide Research and training on microfabrication of microfluidic devices for a high-throughput screening using soft lithography and 3D printing techniques (20%). IBEC training on the project will be part of the Master's Degree in Innovation and Entrepreneurship in Biomedical Engineering. This master's degree forms part of the Master Technological Innovation in Health (MTiH) programme offered by EIT-Health.

Key Research Facilities, Infrastructure and Equipment

The Nanobioengineering lab offers the necessary infrastructure and facilities required for the completion of this project proposal. Prof. Samitier’s laboratory has access to fully functional infrastructure/equipment to be dedicated to the research field of this project. Moreover, available facilities: (i) IBEC’s MicroFabSpace in micro-nanofabrication and biocharacterisation (class 10,000 cleanroom space and laboratories); (ii) BioSpace Lab for 3D culturing and bioprinting; and (iii) the powerful technological facilities at PCB, UB and UPC including: including Genomics, Proteomics, Confocal Microscopy and Animal Research Facility with SPF areas

Status of Research Premises

BioSpace and Nanotechnology Platform have shared instruments with user fees. Furthermore, the methods developed by Prof. Samitier’s team will be made available to the consortium of the present project.

Previous Involvement in Research and Training Programmes

IBEC possess a strong track record in training of students and postdocs within the Institute. Moreover, IBEC has coordinated or been involved in several European networks including research training networks such as FIBROGELNET (MC-IAPP coordinated by IBEC), IMMUNONANOMAP (ITN) and NANOMICROWAVE (ITN). Prof. Samitier’s commitment to ER & ESR training is reflected by being scientific in charge, within the last 5 years, of 10 postdocs, 12 PhD students already graduated, and many Master Students graduate developing their projects in the laboratory.

Current Involvement in Research and Training Programmes

IBEC is currently coordinating two MSCA-ITN-ETN projects (SPM2.0 and THERACAT), one MSCA-COFUND (BEST, for training of ER) and acting as beneficiary of other two MSCA-ITN-ETN projects (ASCTN-Training and BORGES). Prof. Samitier’s total funds under management: an average of 0.6 M/year during the last 5 years; Among them highlight the following formative grants: (i) Two FPI (PhD) fellowships from the Spanish Ministry of Economy and Competitiveness (MINECO) (ii) MSCA-COFUND postdoctoral fellowship, BEST project (MSCA-COFUND-2015-712754), (iv) Severo Ochoa PhD fellowship MINECO and (v) PhD fellowship (MSCA-ITN-2018- 813851). Moreover, 5 Postdoctoral Researchers, 5 PhD students and 1 Master Students with on-going projects, supervised by Prof. Samitier, are still active.

Relevant Publications and/ or Research/ Innovation Product

• A.Lagunas, et al. Nature Communications 9, (1), 5157 (2018) • I.Casanellas, et al. Frontiers in Bioengineering and Biotechnology 6, Article 128 (2018) • A.García-Lizarribar, et al. Macromolecular Bioscience , 18, (10), 1800167 (2018) • Urrios, et al. Lab on a Chip, 2016, 16, 2287-2294 • L. Rigat et al. RSC Advances, 2015, 5, 7423-7425